RT Journal Article
SR Electronic
T1 Elastography strain ratio in the staging of mediastinal lymph nodes
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3562
VO 44
IS Suppl 58
A1 Ales Rozman
A1 Mateja Marc Malovrh
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P3562.abstract
AB Ultrasound elastography is an imaging procedure, used to assess the biomechanical characteristics of tissue. Comparing two areas of tissue allows numeric display of strain ratios. The aim of this study was to compare EBUS elastography strain ratio in staging of mediastinal lymph nodes in lung cancer patients with tissue diagnosis as a gold standard.EBUS bronchoscopy was performed on consenting patients referred to bronchoscopy for diagnosis and staging of lung cancer. Real-time elastography with strain ratio measurements was performed using pre-production prototype model EBUS center EU-Y0008 and BF-UC180F linear ultrasound bronchoscopes (Olympus Tokyo, Japan). Elastoghaphy evaluation was performed before EBUS-TBNA. The main outcome was the accuracy of strain ratio in differentiating between benign and malignant lymph nodes.Sixty-six mediastinal lymph nodes in 27 patients were evaluated. Malignant infiltration was confirmed in 34 (51.5%) lymph nodes by EBUS-TBNA and/or surgically. The area under the receiver operating characteristic curve for strain ratio was 0.91 (95% CI 0.83 – 0.98, p < 0.0001). At strain ratio ≥ 8 the accuracy for malignancy prediction was 89.4% (sens. 88.2%, spec. 90.6%, PPV 90.9%, NPV 87.9%).EBUS elastography strain ratio is a promising new technique for staging of mediastinal lymph nodes in patients with lung cancer. It may help in the selection of biopsy spot, complement EBUS-TBNA or even reduce the number of punctures.