@article {GorinovaP243, author = {Yulia Gorinova and Olga Simonova and Yulia Lashkova and Maya Bakradze}, title = {Hypertonic saline in children with bronchiolitis}, volume = {44}, number = {Suppl 58}, elocation-id = {P243}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Background. Acute viral bronchiolitis is the most frequent infectious disease of the lower airways in the first year of life with hospitalisation rates of about 2\%. It is caused by respiratory syncitial virus in 90\%. The clinical syndrome is characterized by rales, expiratory wheezing, tachypnoea, retractions, and hyperinflation. Awakening interest on treating these children with hypertonic saline has recently been observed.Methods. 15 children (mean age 10,25 {\textpm}7 month, range 3-24 months) with wheezing were enrolled in this study: 7 patients were hospitalized on first week of disease (group 1) and 8 patients- on second (group 2). All patients were prescribed oxygen therapy, bronchodilators, inhalation steroids, antibiotics if needed and 4 ml of Hypertonic Saline (HS) 3\% 2 times a day. Duration of treatment with HS was 14 days. Oxygen saturation, breathe frequency and duration of staying in department were regarded as main outcomes.Results. Early inclusion (first week) of HS in treatment of wheezing was followed by more quick normalization of O2 saturation (p \<0.05), breathe frequency (p \<0.05) and shorter duration of staying (p \<0.05) compare with patients from second group.View this table:Table 1 Outcomes in patients with bronchiolitisConclusion. Using HS inhalations at early stage promotes more quick recovery in children with wheezing.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P243}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }