PT  - JOURNAL ARTICLE
AU  - Igor Klimanov
AU  - Svetlana Soodaeva
AU  - Tatyana Eliseeva
AU  - Natalia Popova
AU  - Lidiya Nikitina
AU  - Nailya Kubysheva
AU  - Natalia Geppe
TI  - Exhaled breath condensate pH in assessment of childhood asthma control
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1765
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1765.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1765.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Exhaled breath condensate (EBC) pH value is considered as a marker of airway inflammation in asthma, but the possibility of its usage for asthma monitoring in children is not completely obvious.The study included 55 children with atopic asthma aged 5 - 17 years with diagnosed upper respiratory tract infection. Asthma control was evaluated by the ACQ test, which was carried out in two variants: ACQ-5 (symptoms during the week) and ACQ-diary (symptoms during the day). EBC was collected using the “R-tube”. The pH values were measured by the pH-meter after 10 minutes degassing with argon at flow rate of 250 ml/min.There were no differences in EBC pH between the groups with different asthma control according to ACQ-5 test: full control (ACQ-5<0,75) pH = (6,94±0,42), partial control (ACQ-5 from 0,75 to 1,5) – (6,75±0,65), no control (ACQ-5>1,5) – (6,85±0,63); p=0.84. While using ACQ-diary test, it was found that the average EBC pH decreased monotonously with increase of symptoms severity: ACQ-diary<0,75 pH=(7,14±0,46), ACQ-diary from 0,75 to 1,5 – (6,59±0,37), ACQ-diary>1,5 – (5,94±0,40); p=0.0001. The EBC pH is more likely to characterize the momentary state of a patient and fails to be a marker of the long-lasting state of the respiratory tract.Thus, the deaerated EBC pH may be useful tool for monitoring of asthma control in asthmatic children. However, this parameter is informative only for the evaluation of the current state of the airways due to its high lability.