RT Journal Article
SR Electronic
T1 Diaskintest®- screening method in mass examination of the child population for tuberculosis in Russia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2600
VO 44
IS Suppl 58
A1 Valentina Aksenova
A1 Nadezhda Klevno
A1 Tatiana Sevostyanova
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2600.abstract
AB In Russia there is a new effective way to identify initial presentation of tuberculosis - Diaskintest® ( DST ), which is a combination of two antigens (ESAT / CFP) presented in virulent strains of mycobacterium tuberculosis and absent in the vaccine strain BCG and non-tuberculous mycobacteria. As opposed to QuantiFERON TB and T- SPOT widely used in other countries, DST injected intradermally and causes specific cutireaction of delayed hyperresponsiveness in people with TB infection. Individuals vaccinated with BCG and noninfected by mycobacterium tuberculosis have no reaction to DST.The aim of the investigation is to study effectiveness of this test alternatively to skin test with PPDL (Mantoux test with 2TE) in conditions of mass screening for tuberculosis.The investigation included healthy children (7-14 years) and adolescents (15-17 years). Over 44% of them had positive reactions to tuberculin. All children (n = 1238) were examined by the DST. Positive reactions were noted only in 4%. After X-ray examination 7 patients revealed local tuberculous changes. Thus, as a result of examination all school children and teenagers by the DST, identifying of local tuberculosis was 0.56%.Conclusion. DST has a high specificity using the secretory proteins ESAT-6 and CFP-10. Introduction into medical practice of new method of tuberculosis diagnosis as a screening method of children examination will allows sharply improve the quality of tuberculosis infection diagnosis, reduce material costs for tuberculosis detection in children and improve the epidemiological situation of tuberculosis in general.