RT Journal Article
SR Electronic
T1 Cardiopulmonary exercise test (CPET) may show initial right cardiac dysfunction in patients with moderate-severe chronic obstructive pulmonary disease (COPD)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3491
VO 44
IS Suppl 58
A1 Laura Malagrinò
A1 Giulia Parri
A1 Frank Dini
A1 Francesco Costa
A1 Sandra Antonelli
A1 Gianna De Cusatis
A1 Claudia De Simone
A1 Sabrina Santerini
A1 Barbara Vagaggini
A1 Pierluigi Paggiaro
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/3491.abstract
AB Background: Cardiovascular comorbidity is frequent and may contribute to exercise limitation as showed by CPET.Aim: To assess if CPET is sensitive in detecting alterations in cardiac function in COPD pts as assessed by echocardiography.Methods: 60 COPD pts (mean FEV1=56.8%) performed CPET and echocardiography.Results: We focused on right cardiac dysfunction parameters: PAPs (systolic Pulmonary Artery Pressure), TAPSE (Tricuspid Annular Plane Systolic Excursion) and RVD/LVEDD (Right Ventricular Diameter, Left Ventricular End-Diastolic Diameter).The Pearson bivariate analysis showed a direct correlation between: peak O2-pulse and TAPSE (r=0.434, p=0.001); peak Ve/VO2 (absolute and %pred) and PAPs (r=0.301, p=0.019 and r=0.322, p=0.012, respectively); peak Ve/VCO2 and PAPs (r=0.262, p=0.043).Dividing echographic parameters in tertiles and performing oneway Anova test, on the basis of TAPSE (<21;21-26;>26 mm) there were differences in O2-pulse (Table 1); on the basis of PAPs (<36;36-42:>42 mmHg) there were differences in VO2 max (%pred) (Table 2)Performing independent T-test, pts with higher RVD/LVEDD (>60%) had a lower peak O2-pulse (mean=13,2*; 92,1%^) versus those with lower ratio (mean=15,453*; 111,95%^) (*p=0.027; ^p=0.012)Conclusion: In moderate-severe COPD pts, CPET might be a sensitive tool to detect right cardiac dysfunction and pulmonary hypertension.