PT - JOURNAL ARTICLE AU - Laura Malagrinò AU - Giulia Parri AU - Frank Dini AU - Francesco Costa AU - Sandra Antonelli AU - Gianna De Cusatis AU - Claudia De Simone AU - Sabrina Santerini AU - Barbara Vagaggini AU - Pierluigi Paggiaro TI - Cardiopulmonary exercise test (CPET) may show initial right cardiac dysfunction in patients with moderate-severe chronic obstructive pulmonary disease (COPD) DP - 2014 Sep 01 TA - European Respiratory Journal PG - 3491 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/3491.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/3491.full SO - Eur Respir J2014 Sep 01; 44 AB - Background: Cardiovascular comorbidity is frequent and may contribute to exercise limitation as showed by CPET.Aim: To assess if CPET is sensitive in detecting alterations in cardiac function in COPD pts as assessed by echocardiography.Methods: 60 COPD pts (mean FEV1=56.8%) performed CPET and echocardiography.Results: We focused on right cardiac dysfunction parameters: PAPs (systolic Pulmonary Artery Pressure), TAPSE (Tricuspid Annular Plane Systolic Excursion) and RVD/LVEDD (Right Ventricular Diameter, Left Ventricular End-Diastolic Diameter).The Pearson bivariate analysis showed a direct correlation between: peak O2-pulse and TAPSE (r=0.434, p=0.001); peak Ve/VO2 (absolute and %pred) and PAPs (r=0.301, p=0.019 and r=0.322, p=0.012, respectively); peak Ve/VCO2 and PAPs (r=0.262, p=0.043).Dividing echographic parameters in tertiles and performing oneway Anova test, on the basis of TAPSE (<21;21-26;>26 mm) there were differences in O2-pulse (Table 1); on the basis of PAPs (<36;36-42:>42 mmHg) there were differences in VO2 max (%pred) (Table 2)Performing independent T-test, pts with higher RVD/LVEDD (>60%) had a lower peak O2-pulse (mean=13,2*; 92,1%^) versus those with lower ratio (mean=15,453*; 111,95%^) (*p=0.027; ^p=0.012)Conclusion: In moderate-severe COPD pts, CPET might be a sensitive tool to detect right cardiac dysfunction and pulmonary hypertension.