@article {Malagrin{\`o}3491, author = {Laura Malagrin{\`o} and Giulia Parri and Frank Dini and Francesco Costa and Sandra Antonelli and Gianna De Cusatis and Claudia De Simone and Sabrina Santerini and Barbara Vagaggini and Pierluigi Paggiaro}, title = {Cardiopulmonary exercise test (CPET) may show initial right cardiac dysfunction in patients with moderate-severe chronic obstructive pulmonary disease (COPD)}, volume = {44}, number = {Suppl 58}, elocation-id = {3491}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Background: Cardiovascular comorbidity is frequent and may contribute to exercise limitation as showed by CPET.Aim: To assess if CPET is sensitive in detecting alterations in cardiac function in COPD pts as assessed by echocardiography.Methods: 60 COPD pts (mean FEV1=56.8\%) performed CPET and echocardiography.Results: We focused on right cardiac dysfunction parameters: PAPs (systolic Pulmonary Artery Pressure), TAPSE (Tricuspid Annular Plane Systolic Excursion) and RVD/LVEDD (Right Ventricular Diameter, Left Ventricular End-Diastolic Diameter).The Pearson bivariate analysis showed a direct correlation between: peak O2-pulse and TAPSE (r=0.434, p=0.001); peak Ve/VO2 (absolute and \%pred) and PAPs (r=0.301, p=0.019 and r=0.322, p=0.012, respectively); peak Ve/VCO2 and PAPs (r=0.262, p=0.043).Dividing echographic parameters in tertiles and performing oneway Anova test, on the basis of TAPSE (\<21;21-26;\>26 mm) there were differences in O2-pulse (Table 1); on the basis of PAPs (\<36;36-42:\>42 mmHg) there were differences in VO2 max (\%pred) (Table 2)Performing independent T-test, pts with higher RVD/LVEDD (\>60\%) had a lower peak O2-pulse (mean=13,2*; 92,1\%^) versus those with lower ratio (mean=15,453*; 111,95\%^) (*p=0.027; ^p=0.012)Conclusion: In moderate-severe COPD pts, CPET might be a sensitive tool to detect right cardiac dysfunction and pulmonary hypertension.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/3491}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }