PT - JOURNAL ARTICLE AU - Nuri Tutar AU - Nur Aleyna Kemik AU - Insu Yilmaz AU - Cevat Yazici AU - Ferhan Elmali AU - Hakan Buyukoglan AU - Asiye Kanbay AU - Ali Dogan AU - Fatma Sema Oymak AU - Inci Gulmez AU - Ramazan Demir TI - Is serum cystatin C a predictor of acute pulmonary thromboembolism in patients with normal renal function? DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2408 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2408.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2408.full SO - Eur Respir J2014 Sep 01; 44 AB - Early diagnosis is the key point in the management of acute pulmonary thromboembolism (PTE). There are no reports in the literature comparing the serum cystatin C levels in patients with acute PTE and normal volunteers. Therefore, in this study, we analyzed 50 acute PTE patients and 45 healthy volunteers with normal renal function. The serum cystatin C level was significantly higher in the PTE group than in the non-PTE group [1.08 mg/dL (IQR 0.79-1.56) and 0.85 mg/dL (IQR 0.77-1.03), respectively, p=0.017]. When determining the presence of PTE, the highest value of sensitivity and specificity was set at a cut-off value of 1.15 mg/dL with 93.3% specificity, 46.0% sensitivity, 88.5% PPV and 60.9% NPV. In the multivariate model cystatin C was significantly associated with the presence of PTE (OR: 12.34, 95% CI 2.64-57.75).In conclusion, cystatin C may be an indicator of acute PTE in patients with normal renal function.