RT Journal Article
SR Electronic
T1 The incidence of chronic thromboembolic pulmonary hypertension secondary to acute pulmonary thromboembolism
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2318
VO 44
IS Suppl 58
A1 Ismail Kayaalp
A1 Yelda Varol
A1 Pinar Cimen
A1 Fatma Demirci Ucsular
A1 Nuran Katgi
A1 Mehmet Unlu
A1 Cenk Kirakli
A1 Salih Zeki Guclu
A1 Oktay Ergene
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2318.abstract
AB Chronic thromboembolic pulmonary hypertension(CTEPH) is a curable and preventable complication with a substantial incidence leading to severe morbidity and mortality.The aim of the study was to find out the incidence of CTEPH secondary to acute pulmonary thromboembolism(PTE) using non-invasive procedures such as ventilation/perfusion(V/Q) scintigraphy and pulmonary multidetector CT(MDCT)angiography.The study included a total of 99 patients diagnosed with initial PTE between January 2010 and December 2012.The patients who received anticoagulant therapy at least for 3 months underwent transthoracic echocardiography(TTE)(N=85).Thirtyone patients with a SPAP value>30mmHg and/or an evidence of right ventricular dysfunction in TTE underwent pulmonaryangiography and V/Q scintigraphy.The patients with an evidence of residual chronic thromboembolic signs in MDCTpulmonary angiography and/or segmental perfusion defect(s) in V/Q scintigraphy underwent rightheart catheterization(RHC)(N=7).During diagnosis,24 subjects were considered having massive,61 submassive and 14 non-massive PTE. Nineteen patients(19,1%) received thrombolythic therapy.Other 80 patients(80.8%) received standard anticoagulant therapy.In 79.8% of patients,thromboembolism was bilateral and it was unilateral in 21.8%.After a minimum of 1 year,and maximum of 2 years follow up five subjects(5.5%) were diagnosed with CTEPH.The univariate analysis showed no association between the development of CTEPH and factors like;age,etiologic risk factors for PTE,receiving thrombolytic treatment,prevalence and type of PTE.Potentially preventabl complication of PE;CTEPH had a substantial incidence during follow-up.