PT  - JOURNAL ARTICLE
AU  - Berta Sáez
AU  - Juan Grignola
AU  - Manuel López Meseguer
AU  - Enrique Domingo
AU  - Cristina Berastegui
AU  - Carlos Bravo
AU  - Antonio Roman
TI  - Relation between pulmonary arterial remodeling and parenchymal disease in severe COPD and interstitial lung disease patients
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2340
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2340.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2340.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Pulmonary vasculopathy relation with lung function is analyzed in COPD and interstitial lung disease (ILD) candidates for lung transplantation (LT) with precapillary pulmonary hypertension (PH).106 patients (p) preLT, NYHA 3-4, 41 COPD (59±5 yo, 9 fem), 65 ILD (60±7 yo, 19 fem) were studied with right heart catheterization and IVUS in medium sized pulmonary arteries (PA). Pulmonary hemodynamics, local PA elastic modulus (EM: diastolic lumen area x pulse pressure/(systolic-diastolic lumen area)) and lung function tests were collected.View this table:Characterictics of the population16% had wedge pressure ≥ 15 mmHg and were excluded. 48% COPD and 43% ILP had PH. EM was obtained in 18/31 COPD and 28/58 ILD. Arterial oxygen pressure was inversely correlated with mPAP in both, COPD (r=-0.44, p<0.01) and ILD (r=-0.35, p<0.01). ILD had higher EM than COPD (p<0.05). FEV1 and EM correlated in COPD but FVC and EM did not correlate in ILD. Neither FEV1 nor CVF correlated with mPAP.COPD and ILD have different pulmonary vasculopathy. Only COPD correlated parenchymal and vascular disease in the presence of PH, suggesting different pathogenic pathways of PH and vascular remodeling in both diseases.