RT Journal Article
SR Electronic
T1 Outdoor fungal spores are associated with child asthma hospitalisations - a case-crossover study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2919
VO 44
IS Suppl 58
A1 Rachel Tham
A1 Shyamali Dharmage
A1 Philip Taylor
A1 Ed Newbigin
A1 Mimi L.K. Tang
A1 Don Vicendese
A1 Rob J. Hyndman
A1 Michael J. Abramson
A1 Bircan Erbas
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/2919.abstract
AB IntroductionAsthma can be exacerbated by exposure to various fungal spores and Human Rhinovirus [HRV], but current understanding of the importance of fungal exposure to child asthma hospitalisations is limited. Moreover the interaction between HRV and fungal spore exposure on admission has not been examined.AimTo investigate the role of outdoor fungal spores in child asthma hospitalisations and if HRV modifies any such effect.MethodsWe conducted a case-crossover study of 644 child asthma hospitalisations in Melbourne, Australia (2009–11). On admission, participants had nasal and throat swabs that were tested using a sensitive nested multiplex PCR for HRV infection. Daily ambient spore counts of 14 fungi species were obtained using a Burkard Volumetric spore trap. Conditional logistic regression assessed the role of fungi adjusting for confounders. Interaction terms were included if there was evidence of effect modification from HRV. Results are presented as odds ratios [OR] per unit increase in daily number of fungi spores/m3 of air sampled.ResultsOverall, higher risk of hospitalisation was observed when participants were exposed to Alternaria (OR=1.011, 95%CI 1.004-1.017), Coprinus (1.009, 1.000-1.017), Leptosphaeria (1.001, 1.000-1.013) independent of air pollution, HRV and sensitization to common allergens. There was evidence of effect modification by HRV in boys exposed to Leptosphaeria (1.028, 1.006-1.050) and Ganoderma (1.320, 1.048-1.660). No evidence of HRV effect modification in girls.ConclusionSome fungal genera are associated with increased risk of asthma hospitalisation in both sexes but the risk increased with two specific fungal genera in boys infected with HRV.