RT Journal Article
SR Electronic
T1 The protective effect of BCG vaccination against mycobacterium tuberculosis infection in children: A systematic review
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4478
VO 44
IS Suppl 58
A1 Anjana Roy
A1 Michael Eisenhut
A1 Ross Harris
A1 Laura Rodrigues
A1 Saranya Sridhar
A1 Stephanie Habermann
A1 Luke Snell
A1 Punam Mangtani
A1 Ifedayo Adetifa
A1 Ajit Lalvani
A1 Ibrahim Abubakar
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/4478.abstract
AB Background: The objective of the study was to determine whether Bacillus Calmette-Guerin (BCG) vaccination protects against Mycobacterium tuberculosis infection as assessed by interferon gamma release assays (IGRA) in children.Methods: Systematic review of observational cohort studies conducted as part of investigation of children less than 16 years of age recently exposed to infectious tuberculosis. Risk estimates were combined using random effects meta-analytic models.Results: The primary analysis included 14 studies and 3855 participants and estimated an overall risk ratio (RR) of 0.81(95% CI = 0.71-0.92), indicating a protective efficacy of 19% against infection among vaccinated children after exposure compared to unvaccinated children. The observed protection was similar when estimated using the two types of IGRA test (ELISpot or QuantiFERON).Restricting the analysis to the 6 studies (n=1748) with information on progression to active tuberculosis at the time of screening showed protection against infection of 27% (RR 0.73 (0.61-0.87)) compared to 71% (RR 0.29 (0.15-0.58)) against active tuberculosis. Among those infected, protection against progression to disease was 58% (RR = 0.42 (95% CI = 0.23-0.77))Conclusions: BCG protects against M. tuberculosis infection as well as against progression from infection to disease.