RT Journal Article
SR Electronic
T1 Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 38
OP 50
DO 10.1183/09031936.00130014
VO 45
IS 1
A1 Martin Adam
A1 Tamara Schikowski
A1 Anne Elie Carsin
A1 Yutong Cai
A1 Benedicte Jacquemin
A1 Margaux Sanchez
A1 Andrea Vierkötter
A1 Alessandro Marcon
A1 Dirk Keidel
A1 Dorothee Sugiri
A1 Zaina Al Kanani
A1 Rachel Nadif
A1 Valérie Siroux
A1 Rebecca Hardy
A1 Diana Kuh
A1 Thierry Rochat
A1 Pierre-Olivier Bridevaux
A1 Marloes Eeftens
A1 Ming-Yi Tsai
A1 Simona Villani
A1 Harish Chandra Phuleria
A1 Matthias Birk
A1 Josef Cyrys
A1 Marta Cirach
A1 Audrey de Nazelle
A1 Mark J. Nieuwenhuijsen
A1 Bertil Forsberg
A1 Kees de Hoogh
A1 Christophe Declerq
A1 Roberto Bono
A1 Pavilio Piccioni
A1 Ulrich Quass
A1 Joachim Heinrich
A1 Deborah Jarvis
A1 Isabelle Pin
A1 Rob Beelen
A1 Gerard Hoek
A1 Bert Brunekreef
A1 Christian Schindler
A1 Jordi Sunyer
A1 Ursula Krämer
A1 Francine Kauffmann
A1 Anna L. Hansell
A1 Nino Künzli
A1 Nicole Probst-Hensch
YR 2015
UL http://erj.ersjournals.com/content/45/1/38.abstract
AB The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m−3 increase in NO2 exposure was associated with lower levels of FEV1 (−14.0 mL, 95% CI −25.8 to −2.1) and FVC (−14.9 mL, 95% CI −28.7 to −1.1). An increase of 10 μg·m−3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (−44.6 mL, 95% CI −85.4 to −3.8) and FVC (−59.0 mL, 95% CI −112.3 to −5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe. The ESCAPE study finds that, even at very low levels, air pollution has adverse effects on lung function in adults http://ow.ly/A1ssB