TY - JOUR T1 - Clinical features of microscopic polyangiitis with usual interstitial pneumonia-like fibrosis in comparison with idiopathic pulmonary fibrosis JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P719 AU - Wen Zhao AU - Huaping Dai AU - Yan Liu AU - Chen Wang Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P719.abstract N2 - Introduction Microscopic polyangiitis (MPA) patients presented with usual interstitial pneumonia (UIP) pattern are likely misdiagnosed as idiopathic pulmonary fibrosis (IPF). Aims To explore the clinical features of MPA with UIP-like and the difference between MPA and IPF. Methods The study population was composed of 36 patients diagnosed as MPA with UIP-like pattern on chest HRCT (MPA/UIP) in Beijing Chao-Yang Hospital of Capital Medical University from Aug. 2003 to Aug. 2013 (male/female ratio, 1.77:1, age 67.25±11.50 years). 72 patients with IPF (male/female ratio, 3.5:1, age 63.96±10.00 years) admitted in the same time were analyzed. Results Many non-specific inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immunoglobulin G, ferritin and peripheral white blood cell count, neutrophilic granulocyte percent, fibrinogen, D-dimer were increased in MPA/UIP patients (P<0.05). Besides positive ANCA, rheumatoid factor (RF) was mostly positive in MPA/UIP patients (11/28 vs 5/52, P=0.002). Abnormal blood urea nitrogen and serum creatinine, mild anemia and hypoproteinemia and hematuria and/or proteinuria were more common in MPA/UIP patients(P<0.05). However, serum carcinoembryonic antigen and CA199 were higher in IPF patients(P<0.05). Conclusions MPA patients with UIP-like pattern have abnormality of more laboratory examinations and can be differentiated with IPF by comprehensive analysis of clinical and laboratory findings. ER -