PT  - JOURNAL ARTICLE
AU  - Oymak, Fatma Sema
AU  - Balkanli, Suleyman
AU  - Oymak, Oktay
TI  - Secondary organizing pneumonia (BOOP)-associated with granulomatosis with polyangiitis [Wegener granulomatosis (WG)]: A clinicoradiological study of 19 cases
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3799
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3799.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3799.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - The histopathological features of WG include necrotizing granulomatous vascular inflammation, but BOOP like variant has also been reported. We have recently observed a substantial number of patients with BOOP -associated with WG.This study was undertaken to elucidate the clinical, and radiological features of this form of WG. Clinical information, chest radiographic findings, and follow-up data on the patients with WG were obtained from hospital records. Patients in a university hospital with WG were selected according to American College of Rheumatology (ACR) criteria.The 19 patients ranged in age 27 from to 72 years (mean: 46 years) and included 6 men (31%) and 13 women (69%). Cough, fever, hemoptysis, and dyspnea were the most common complaints. The WG was limited form to the lung and upper airways in 14 patients (73%). Renal involvement was present in five patients (27%). The antineutrophil cytoplasmic antibodies (ANCA)test was performed in all patients, the result was negative in 14 patients (73%). Chest tomography showed multiple nodules in 15 cases (%78) , 5 (27%) of which were associated with cavitation. Two patients (15%) had alveolar hemorrhage . When confronted by multiple nodules with /or without cavitation together with clinical signs of inflammation, the clinician must also consider the possibility of immunological disorders, such as WG, where BOOP is a rather common feature associated with vasculitis. A careful examination for extrapulmonary signs of vasculitis, and the presence of ANCA is, therefore, necessary in such cases.