RT Journal Article SR Electronic T1 Immune status in bronchopulmonary displasia JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3306 VO 44 IS Suppl 58 A1 Ilgar Mustafayev A1 Lala Allahverdiyeva A1 Alevtina Bogdanova YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P3306.abstract AB Objective: To evaluate the state of cellular immunity in bronchopulmonary dysplasia (BPD ) .Materials and methods : The study involved 103 patients with BPD at the age of first days of life to 14 years. Analyzed such cell protection indicators as CD3 , CD4, CD8, CD4/CD8, CD20. Studies conducted in the acute period of the disease and in remission.Results: The status of all children in the acute period was extremely grave. All patients underwent mechanical ventilation with high doses of oxygen. RDS occurred in 96 % of patients. The first study of cellular immunity was conducted in the neonatal period and characterized by inhibition of T-cells : CD3 (48,6 ± 0,7 p <0,001), CD4 (42,1 ± 0,9 p <0,001), CD8 (25,4 ± 1.0 p <0,01), CD4/CD8 (1,89 ± 0,1 p < 0.01). The total number of B cells remained normal: CD20 (16,4 ± 0,7 p < 0.001 ) . In remission observed persistent but moderate ( 47%) or minor (53%) bronchial obstruction without signs of intoxication . There was a trend toward normalization of T-cell immunity : CD3 (55,2 ± 0,6 p <0,001), CD4 (52,6 ± 0,8 p <0,001), CD8 (30,4 ± 0,7 , p <0.001 ), CD4/CD8 (1,79 ± 0,06 p <0,001). The B-lymphocyte level was within normal limits: CD20 (16,9 ± 0,4 p> 0.5 ) .Conclusion: The immune status in BPD is characterized by inhibition of T-cell in an acute phase of the disease and its gradual normalization in remission . B-cell link in BPD does not suffer.