PT  - JOURNAL ARTICLE
AU  - Katalin Fekete
AU  - Afroditi Boutou
AU  - Nikolaos Chavouzis
AU  - Athanasia Pataka
AU  - Georgia Pitsiou
AU  - Ioanna Athanasiou
AU  - Theodoros Kontakiotis
AU  - Paraskevi Argyropoulou
AU  - Ioannis Kioumis
TI  - Impact of overnight sleep on resting metabolic rate in OSA patients and controls
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1737
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1737.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1737.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - IntroductionObstructive sleep apnea (OSA) syndrome has been previously associated with sympathetic overactivity, hormonal dysregulation and metabolic abnormalities.AimTo investigate the potential variation of resting metabolic rate (RMR) just before and after an overnight sleep, in patients with OSA and in non-OSA controls.Material-MethodsThis is a nested case-control study. From a consecutive population referred for sleep evaluation between June 2007 and December 2011, subjects with OSA constituted the group of patients and subjects without OSA or other sleep disorders, the group of controls. All patients underwent anthropometric measurements, night polysomnography and evaluation of resting metabolic rate (RMR) before and after nocturnal sleep. RMR was compared before and after sleep in each group utilizing paired t-test or Wilcoxon signed rank test, according to distribution of values; level of p>0.05 was considered significant.ResultsThe study population constituted of 158 OSA patients (58.2% male; 46.7±12.2 years old) and 20 controls (90% male; 51.3±11.7 years old). In OSA patients RMR measured before and after overnight sleep was significantly different (1869.8±869.5 vs. 1709.6±685.9, p<0.001). Sub-analysis identified that pre and post differences were significant among patients with moderate (apnea/hypopnea index (AH)=15-30/h) and severe (AH>30/h) but not in the ones with mild (AH=5-15/h) syndrome. In controls no difference was noted in RMR before and after overnight sleep (1416.4±501.4 vs. 1344.2±565.2, p=0.279).ConclusionPatients with moderate or severe OSA establish a significant variation in RMR before and after overnight sleep, compared to non-OSA controls.