PT  - JOURNAL ARTICLE
AU  - Jung-Wan Yoo
AU  - Kyung-Wook Jo
AU  - Bo-Hyung Kang
AU  - Mi Young Kim
AU  - Bin Yoo
AU  - Chang-Keun Lee
AU  - Yong-Gil Kim
AU  - Suk-Kyun Yang
AU  - Jeong-Sik Byeon
AU  - Kyung-Jo Kim
AU  - Byong Duk Ye
AU  - Tae Sun Shim
TI  - Mycobacterial diseases developed during anti-tumour necrosis factor-α therapy
AID  - 10.1183/09031936.00063514
DP  - 2014 Nov 01
TA  - European Respiratory Journal
PG  - 1289--1295
VI  - 44
IP  - 5
4099  - http://erj.ersjournals.com/content/44/5/1289.short
4100  - http://erj.ersjournals.com/content/44/5/1289.full
SO  - Eur Respir J2014 Nov 01; 44
AB  - Nontuberculous mycobacterial (NTM) disease and tuberculosis (TB) develop during anti-tumour necrosis factor (TNF)-α therapy. We compared clinical characteristics and outcomes between the two diseases. A total of 1165 patients were screened for TB and treated with TNF-α antagonists from July 2004 to July 2013 for the following conditions: inflammatory bowel disease (n = 422), rheumatoid arthritis (n = 320), and ankylosing spondylitis (n = 389). TB and NTM disease were diagnosed at baseline screening in four and three patients, respectively, and developed during anti-TNF-α therapy in 19 and six patients, respectively. The incidence rate of TB and NTM disease was 747.7 per 100 000 and 238.2 per 100 000 person-years, respectively. Patients with NTM disease were older, with a greater proportion of females. All cases of NTM disease involved the lung, with rheumatoid arthritis (83.3%) being the most frequent underlying disease. The most common radiological feature was consolidation in NTM disease, and honeycombing was present in two rheumatoid arthritis patients with NTM disease. The most common pathogen was Mycobacterium intracellulare (n = 3) followed by Mycobacterium avium (n = 2). Both the NTM and TB group showed favourable outcomes. The clinical characteristics differed between NTM disease and TB that developed on anti-TNF-α agents, but clinical outcomes were favourable in both diseases. Clinical characteristics differ between nontuberculous mycobacterial disease and TB that develop on anti-TNF-α agents http://ow.ly/xSQ0o