TY - JOUR T1 - The PROactive innovative conceptual framework on physical activity JF - European Respiratory Journal JO - Eur Respir J SP - 1223 LP - 1233 DO - 10.1183/09031936.00004814 VL - 44 IS - 5 AU - Fabienne Dobbels AU - Corina de Jong AU - Ellen Drost AU - Janneke Elberse AU - Chryssoula Feridou AU - Laura Jacobs AU - Roberto Rabinovich AU - Anja Frei AU - Milo A. Puhan AU - Willem I. de Boer AU - Thys van der Molen AU - Kate Williams AU - Hillary Pinnock AU - Thierry Troosters AU - Niklas Karlsson AU - Karoly Kulich AU - Katja Rüdell AU - the PROactive consortium Y1 - 2014/11/01 UR - http://erj.ersjournals.com/content/44/5/1223.abstract N2 - Although physical activity is considered an important therapeutic target in chronic obstructive pulmonary disease (COPD), what “physical activity” means to COPD patients and how their perspective is best measured is poorly understood. We designed a conceptual framework, guiding the development and content validation of two patient reported outcome (PRO) instruments on physical activity (PROactive PRO instruments). 116 patients from four European countries with diverse demographics and COPD phenotypes participated in three consecutive qualitative studies (63% male, age mean±sd 66±9 years, 35% Global Initiative for Chronic Obstructive Lung Disease stage III–IV). 23 interviews and eight focus groups (n = 54) identified the main themes and candidate items of the framework. 39 cognitive debriefings allowed the clarity of the items and instructions to be optimised. Three themes emerged, i.e. impact of COPD on amount of physical activity, symptoms experienced during physical activity, and adaptations made to facilitate physical activity. The themes were similar irrespective of country, demographic or disease characteristics. Iterative rounds of appraisal and refinement of candidate items resulted in 30 items with a daily recall period and 34 items with a 7-day recall period. For the first time, our approach provides comprehensive insight on physical activity from the COPD patients’ perspective. The PROactive PRO instruments’ content validity represents the pivotal basis for empirically based item reduction and validation. Conceptual framework as basis of PROactive PRO instruments to assess physical activity from COPD patient perspective http://ow.ly/ytJoS ER -