RT Journal Article
SR Electronic
T1 Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 603
OP 613
DO 10.1183/09031936.00168813
VO 44
IS 3
A1 Payam Dadvand
A1 Mark J. Nieuwenhuijsen
A1 Àlvar Agustí
A1 Jordi de Batlle
A1 Marta Benet
A1 Rob Beelen
A1 Marta Cirach
A1 David Martinez
A1 Gerard Hoek
A1 Xavier Basagaña
A1 Antoni Ferrer
A1 Jaume Ferrer
A1 Robert Rodriguez-Roisin
A1 Jaume Sauleda
A1 Stefano Guerra
A1 Josep M. Antó
A1 Judith Garcia-Aymerich
YR 2014
UL http://erj.ersjournals.com/content/44/3/603.abstract
AB The origin(s) of systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) is unclear. We investigated the impact of exposure to ambient air pollution on systemic biomarkers of inflammation (C-reactive protein (CRP), tumour necrosis factor-α, interleukin (IL)-6, IL-8 and fibrinogen) and tissue repair (hepatocyte growth factor (HGF)) in 242 clinically stable COPD patients (mean age 67.8 years and forced expiratory volume in 1 s 71.3% predicted) in Barcelona, Spain, in 2004–2006. A spatiotemporal exposure assessment framework was applied to predict ambient nitrogen dioxide (NO2) and levels of particles with a 50% cut-off aerodynamic diameter of 2.5 μm (PM2.5) at each participant’s home address during 10 periods of 24 h (lags 1–10) and 1 year prior to the blood sampling date. We used linear regression models to estimate associations between biomarkers and exposure levels. An interquartile range (IQR) increase in NO2 exposure in lag 5 was associated with 51%, 10% and 9% increases in CRP, fibrinogen and HGF levels respectively. We also observed 12% and 8% increases in IL-8 associated with an IQR increase in NO2 exposure in lag 3 and over the year before sampling, respectively. These increases were larger in former smokers. The results for PM2.5 were not conclusive. These results show that exposure to ambient NO2 increases systemic inflammation in COPD patients, especially in former smokers. NO2 exposure increases levels of systemic inflammation biomarkers in COPD patients, especially in former smokers http://ow.ly/sRKnX