TY - JOUR T1 - Importance of concomitant local and systemic eosinophilia in uncontrolled asthma JF - European Respiratory Journal JO - Eur Respir J SP - 1098 LP - 1099 DO - 10.1183/09031936.00118014 VL - 44 IS - 4 AU - Florence N. Schleich AU - Renaud Louis Y1 - 2014/10/01 UR - http://erj.ersjournals.com/content/44/4/1098.abstract N2 - From the authors:We thank C. Persson and L. Uller for their interesting correspondence regarding our recent research paper on the link between systemic and airway eosinophilia and asthma control [1].As there has been a huge controversy on the role of eosinophils in asthma, the purpose of our paper [1] was to report our clinical experience on the relationship between eosinophils and asthma. In our study the link between eosinophil counts and asthma control is significant but not so strong, which is in keeping with the concept of concordant and discordant disease when relating symptoms to inflammation [2]. In fact only airway eosinophilia was directly associated with poor Asthma Control Questionnaire, with an r coefficient of 0.16, while the blood … ER -