RT Journal Article
SR Electronic
T1 Treating peripheral eosinophilia in asthma: Simple and effective
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P835
VO 42
IS Suppl 57
A1 Yew, Ding
A1 Su, Kimberly
A1 Yadavilli, Rajesh
A1 Murthy, Mithun
A1 Burhan, Hassan
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P835.abstract
AB Background:Escalating steroid treatment in asthma based on sputum eosinophilia has been shown to reduce admissions. While sputum cell counting is not practical in all patients, increasing steroid treatment in those asthmatic patients with peripheral eosinophilia is straight forward. We assessed our patient database to see whether those patients with eosinophilia were prescribed more steroid and whether this led to better control.Methods:A retrospective analysis of 100 patients from a dedicated asthma clinic, using case note review, spirometry results, serum eosinophils and total IgE, mini Asthma Quality of Life Questionnaire (AQLQ) and Asthma Control Test (ACT) questionnaire results was carried out. Hypothesis testing using two-way unpaired student’s t test for continuous variables and z-test for proportions.Results:The mean age of our asthmatic population was 49.3years, 77% were female. A significantly greater proportion of patients with blood eosinophilia were on maintainence oral corticosteroids.View this table:Table 1Conclusions:Patients with a blood eosinophilia tend to be on higher BTS Step treatment and a significantly greater portion are on maintainence oral corticosteroids. Perhaps as a consequence of this, there are no significant differences between those with and without eosinophilia with regards to BMI, QoL, control or FEV1 % predicted.