PT - JOURNAL ARTICLE AU - Federica Novelli AU - Giulia Lenzini AU - Manuela Latorre AU - Veronica Seccia AU - Maria Laura Bartoli AU - Laura Malagrinò AU - Federico Lorenzo Dente AU - Pier Luigi Paggiaro TI - Influence of obesity and nasal polyps on severe asthma DP - 2013 Sep 01 TA - European Respiratory Journal PG - P4177 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P4177.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P4177.full SO - Eur Respir J2013 Sep 01; 42 AB - Background: Asthma is often associated with comorbidities that can influence its control, phenotype and response to treatment. Aim of this study is to evaluate the influence of two common comorbidities (obesity and nasal polyps, NP) on pulmonary function, inflammation, asthma control and quality of life in patients with severe asthma (SA).Method: We studied 64 patients with SA. All patients performed spirometry, collection of induced sputum for inflammatory cells, measurement of exhaled nitric oxide (eNO) and ENT visit. Asthma control was evaluated according to GINA guidelines and by ACT questionnaire, quality of life by AQLQ.Results: The percentage of patients with uncontrolled asthma was high (46.9%). Obese asthmatics had a similar functional data than non-obese, but worse asthma control (ACT score: 16 (7-25) vs 21 (10-25), p<0.05; poorly controlled: 71,4% vs 34,9%, p<0.05) and quality of life index (AQLQ score: 4.5 (3.0-6.2) vs 5.1 (2.7-6.7), p<0.05), as well as a trend to have lower sputum eosinophilia (6.6 (0-71.2) vs 17.6 (0-95.6), p=0,07), with no-difference in asthma treatment. Asthmatics with NP showed similar asthma control and quality of life index than asthmatics without NP, but worse spirometry (FEV1 71.1±16.7 vs 81.0±17.3, p<0.05) and higher sputum eosinophilia (29.8 (0.4-95.6) vs 8.5 (0-84.1), p<0.05). In a multivariate analysis taking into account age, sex, FEV1 (% of predicted), obesity, NP and sputum eosinophilia, only the obesity predicted the lack of asthma control (OR: 5.6, CI: 1.4-22.8 p=0.01).Conclusion: In patients with SA, NP is associated with increased eosinophilic airway inflammation and with worse lung function, but has less impact on asthma control and quality of life than obesity.