PT  - JOURNAL ARTICLE
AU  - Francesco Costa
AU  - Laura Malagrinò
AU  - Tommaso Nieri
AU  - Silvana Cianchetti
AU  - Sandra Antonelli
AU  - Giovanna De Cusatis
AU  - Claudia De Simone
AU  - Sabrina Santerini
AU  - Barbara Vagaggini
AU  - Pierluigi Paggiaro
TI  - Systemic inflammation and exercise tolerance in COPD
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P5142
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P5142.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P5142.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background: cardiopulmonary exercise test (CPET) is used to evaluate exercise tolerance in COPD patients. Systemic inflammation (SI) is considered a hallmark of COPD, a number of inflammatory proteins were described in the systemic circulation including C-reactive protein(CRP), tumor necrosis factor alpha (TNF-alfa), interleukins (IL-6 and IL_8).Aim: to evaluate SI in COPD patients with different exercise tolerance.Subject and methods: 45 COPD patients (FEV1%: 52.5; 36male) performed: CPET, pulmonary function tests, measurements of infiammatory cells, IL-8, TNF-alfa and microparticles (MP) in blood and sputum. Patients were divided according to tertiles of VO2/Kg, expression of exercise tolerance. Kruscall-Wallis test was used to compare the groups.Results: we found significant differences between patients with higher and lower exercise tolerance, the last ones having lower sputum eosinophils and higher blood IL-8 and MP. There was no difference among groups for FEV1%pred and TLC%pred.View this table:Table 1Conclusion: in COPD patients higher SI is associated with lower exercise tolerance, suggesting that SI may damage the skeletal muscle conditioning the exercise tolerance.