RT Journal Article SR Electronic T1 Analysis of the patients with community acquired pneumonia treated in MHAT "St. Marina", Varna, Bulgaria for the 2011-2012 period JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2743 VO 42 IS Suppl 57 A1 Vanya Kostadinova A1 Yordan Radkov A1 Iskra Mircheva YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2743.abstract AB Background:Community-acquired pneumonia (CAP) is the most common infectious disease through the world.Aim:To analyze patients with CAP according to C-reactive protein (CRP) levels,CRB-65 and CURB-65 scores,the concomitant diseases,the antibacterial treatment.Methods:A retrospective survey for the period of 2 years that includes 870 consecutive hospitalized patients with CAP,mean age 59,82 ± 16,96 years, 43,6% men (n=379),133 of them were in intensive care unit(ICU).CRB65 and CURB65,CRP,antibiotic treatment,influence of co-morbidity and outcomes have been studied.Results:Prevaling CURB65 score in the ICU is 3 (27,4%) and in the hospital ward 0 (39,3%)(influenced by social factors).There is a significant difference in CRP levels at admission and after treatment among the patients in the hospital ward and these in the ICU(t=–6,284, p< 0,001),as well as among the survived and diseased patients (z=–4,673, p< 0,05).There is no difference in the CRP levels at admission in patients with and without concomitant diseases.After treatment CRP levels are higher in patients with co morbidity (t=–4,723, p< 0,001).There is a statistically significant relationship in CRP levels at admission and:CRB65 (F=8,3607,p=0,000),CURB65(F=8,882,p=0,000),age (F=5,1087,p=0,0004).Adding macrolide to beta-lactam antibiotics do not improve outcomes at the end of the treatment (p>0,05).Quinolones as a part of initial treatment or as a second choice after treatment failure lead to the most significant CRP levels drop (F=10,8694; p=0,0000).Conclusion:Social factors have a large influence in decision making whether to hospitalize patients with CAP. Quinolones improve CRP levels in most.