@article {IshiiP3150, author = {Masanobu Ishii and Yukari Miyamoto and Katsunori Ochiai and Saori Kirishi and Etsuko Tagaya and Kiyoshi Takeyama and Jun Tamaoki}, title = {Clinical characteristics, airway inflammation, and adipocytokines in overweight and obese asthmatics}, volume = {42}, number = {Suppl 57}, elocation-id = {P3150}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Rationale: Obesity affects asthma development, severity, and treatment response. Understanding how obesity influences symptoms, QOL and asthma characteristics is thus necessary to optimize management for this phonotype.Methods: 186 adult patients with mild-to-moderate persistent asthma were enrolled in this study, from which 25 patients whose BMI of \> 25 kg/m2 and 25 normal weight patients were randomly selected. Patients completed ACT and underwent comprehensive pulmonary function testing. Blood samples were collected to measure adipocytokines including IL-6, leptin, adiponectin, PAI-1 and TNF-α. Inflammatory cell counts in induced sputum and NO contents in exhaled air were measured. We also assessed the response to 12-week treatment with FBC.Results: Overweight patients were more likely to be women (p = 0.026), and had older age of disease onset (p = 0.022), lower ACT scores (p = 0.045) and lower serum IgE (p = 0.042). FRC and ERV were less in overweight patients than in normal weight patients (both p \< 0.05), but there were no differences in FVC, FEV1, TLC and RV between two groups. In overweight patients, IL-6, leptin and PAI-1 levels were lower (each p \< 0.04), and there were significant positive correlation between plasma leptin concentration and sputum eosinophil number and ECP contents. After the treatment, among asthma-related measures, the responses of FEV1 and ACT scores were poorer in overweight patients (both p \< 0.05).Conclusion: Overweight is an important phonotypic determinant in asthma. The increased levels of leptin might play a role in eosinophilic airway inflammation, and the responses to inhaled corticosteroid are attenuated in overweight patients.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P3150}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P3150.full.pdf}, journal = {European Respiratory Journal} }