RT Journal Article
SR Electronic
T1 Effect of long-term exposure to traffic-related air pollution on lung function: The ESCAPE project
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1549
VO 42
IS Suppl 57
A1 Martin Adam
A1 Tamara Schikowski
A1 Anne Elie Carsin
A1 Cai Yutong
A1 Margaux Sanchez
A1 Bénédicte Jacquemin
A1 Andrea Vierkötter
A1 Dirk Keidel
A1 Alessandro Marcon
A1 Schindler Christian
A1 Jordi Sunyer Deu
A1 Francine Kauffmann
A1 Ursula Krämer
A1 Anna Hansell
A1 Nino Künzli
A1 Nicole Probst-Hensch
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P1549.abstract
AB Background. Acute air pollution effects on lung function are well established, while the chronic impact of ambient air pollutants on lung function in adults remains poorly understood. Aims. In the ESCAPE study, we investigated the association of residential traffic-related air pollution with level and decline of lung function in the context of five European cohorts of adults (ECRHS, EGEA, NSHD, SALIA, SAPALDIA). Methods. Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was obtained from standardized measurement protocols and land use regression models. Traffic load at the road nearest to participants’ home and on major roads within a 100 meter buffer was assessed. Level and annual decline in the spirometric parameters FEV1, FVC, and FEV1/FVC were considered as outcomes. Study-specific analyses were performed with random effects linear regression adjusting for gender, age, height, BMI, education, smoking status. Cohort-specific results were combined using random-effects meta-analysis. Results. Based on lung function data from 7,613 subjects undergoing spirometry twice over 11 years on average, we observed that a 10 µg/m3 increase in NO2 exposure was associated with lower levels of FEV1 (-13.8 mL (95%CI:-25.82,-2.14)) and FVC (-14.93 mL (-28.73,-1.13)). A higher traffic load at the home address also went along with lower levels of FEV1 and FEV1/FVC. The observed associations were particularly observed in women and generally stronger in participants reporting use of respiratory medication. Conclusions. In this analysis of adults mostly living in urban environments, we observed a lung function decline with increased nitrogen oxide or traffic load exposure.