TY - JOUR T1 - The recent multi-ethnic global lung initiative 2012 (GLI<sub>2012</sub>) reference values don't reflect contemporary Mediterranean spirometry JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2409 AU - Helmi Ben Saad AU - Mohamed Nour Elattar AU - Khaoula Hadj Mabrouk AU - Chiraz Maatoug AU - Sonia Rouatbi Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2409.abstract N2 - Introduction. The applicability of the recent Multi-ethnic reference values derived by the GLI2012 in interpreting spirometry data in Tunisian subjects has not been studied. Aims. To see if GLI2012 Multi-ethnic and Tunisian prediction equations can be used interchangeably while interpreting routine spirometric data. Methods. Spirometric data were recorded from 1192 consecutive spirometry procedures in adults aged 18-63 years. Predicted values and lower limits of normality (LLN) were calculated using both regression equations. Applied definitions: large airway obstructive ventilatory defect (LAOVD): FEV1/FVC &lt; LLN. Small AOVD (SAOVD): FEV1/FVC &gt; LLN and FVC &gt; LLN and FEF25-75% &lt; LLN. Tendency through a restrictive ventilatory defect (TRVD): FEV1 and FVC &lt; LLN. Mixed VD (MVD): FEV1/FVC and FEV1 and FVC &lt; LLN and FEV1 &lt; LLN. Z-scores for spirometry from Mediterranean healthy subjects (n=489) were calculated. If the average z-score deviated by &lt; ±0.40 from the overall mean, the GLI2012 reference values will be considered as reflective of contemporary Mediterranean spirometry.Results: According to Tunisian and GLI2012 reference equations, the percentages of subjects with normal spirometry data, or having LAOVD, or SAOVD or a TRVD or a MVD, were significantly different, respectively, 35% vs 84%, 7% vs 4%, 37% vs 2%; 19% vs 9% and 3% vs 2%. The mean±SD Z-scores of the healthy group were -0.55±0.87 for FEV1, -0.62±0.86 for FVC, 0.10±0.73 for FEV1/FVC, 4.43±0.69 for FEF75% and 0.07±0,93 for FEF25-75%).Conclusion. Our results don’t support the use of the GLI2012 reference ranges to interpret spirometry in Mediterraneans. ER -