TY - JOUR T1 - Microbial aetiology and outcomes of CAP in bronchiectatic patients JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - 4646 AU - Eva Polverino AU - Rosario Menendez AU - Catia Cilloniz AU - Rosanel Amaro AU - Albert Gabarrus AU - Jordi Puig de la Bellacasa AU - Jacobo Sellares AU - Beatriz Montull AU - Josep Mensa AU - Antoni Torres Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/4646.abstract N2 - Background: Non cystic fibrosis-bronchiectasis (NCFBE) are characterised by frequent pneumonia (CAP). Nonetheless, the knowledge on clinical characteristics of CAP in NCFBE is poor and no specific recommendations are currently available.Objectives: to investigate clinical and microbiological characterisation of NCFBE patients with CAP.Methods: prospective, observational study of 3719 CAP patients (2000-2011).Results: we found 130(3.5%) CAP patients with NCFBE that, compared with non-bronchiectatic CAP showed: older age(CAP-NCFBE: 71yrs vs CAP: 65yrs), less male gender (43% vs. 62%), more vaccinations (pneumococcal:40% vs 15%; influenza:61% vs 42%), comorbidities(n≥2: 43% vs 26%), previous antibiotics (37% vs 22%) and inhaled steroids(51% vs 17%)(p<0.05 each). S.pneumoniae was the most frequent isolate (CAP-NCFBE 39%, CAP 42%; p=0.64), followed by mixed aetiology (27.3% vs 12.6%; p<0.01), viruses (7.6% vs 15.4%;p=0.08), atypicals (4.5% vs 8%,NS), E.coli (3% vs 0.9%,NS), Legionella (1.5% vs 6.9%,NS). P aeruginosa was more prevalent among CAP-NCFBE (18.2% vs. 3.0%,p<0.01) especially in mixed aetiology, such as H. influenzae (10.6% vs. CAP 2.7%, p<0.01) while S. aureus (6.1% vs 3.5%, NS) was infrequent. Despite similar mortality (CAP-NCFBE, 3.8% vs CAP 7.2%, NS), and length of hospitalization (median, 6 vs. 7days,p=0.13), NCFBE patients needed more hospitalization (97% vs 84%, p<0.01) and ICU (23.8% vs 16.2%,p<0.03). The presence of NCFBE was a risk factor for ICU (OR:2.9) in CAP (multivariate analysis).Conclusions: CAP-NCFBE patients are usually older and have more comorbidities, present an increased prevalence of mixed aetiology with P. aeruginosa or H. influenzae and an increased risk of hospitalization and ICU. ER -