PT - JOURNAL ARTICLE AU - Laurent Laforest AU - Cheikh Tamberou AU - Marine Ginoux AU - Chu-Philippe Ya AU - Gilles Devouassoux AU - Nicolas Roche AU - Christos Chouaid AU - Eric Van Ganse TI - Factor associated with global mortality in COPD between 2006 and 2011: French claims data DP - 2013 Sep 01 TA - European Respiratory Journal PG - P4719 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P4719.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P4719.full SO - Eur Respir J2013 Sep 01; 42 AB - Background: A good understanding of prognostic factors of death in COPD may contribute to improve disease management. The role of patient and management-related factors during a baseline period on global mortality during the following years was investigated in COPD.Methods: A cohort of patients aged≥45, with documented follow-up and ≥3 dispensations in 2005 of a same drug-class were selected in French Claims data. Drug classes were long-acting beta agonists, short-acting beta agonists (SABAs), short-acting muscarinic antagonists (SAMAs), xanthines, and SAMA/SABA fixed combinations. Cox multivariate models were used to predict global 2006-2011 mortality. Analyzed co-factors were age, gender, dispensing level inhaled bronchodilatator therapy in 2005, free-access-to-care status, long-term-disease status (diabetes, respiratory, cardiovascular, tumoral, and mental diseases) and COPD-related hospitalization in 2005 (1-10, >10 days).Results: The mean annual death rate between 2006 and 2011 of the 4,800 patients (mean age 66, 50% women) was 4.6%. The strongest predicting factors was duration of COPD-related hospitalizations in 2005 (HR=2.0 and 2.3 for hospital stays of 1-10 days and >10 days, respectively), long-term disease status of cancer (HR=1.8), cardiovascular diseases (HR=1.3) and male gender (HR=1.7), p<0.0001 for all. Significant effects were also observed with long-term disease status for mental disorders (p=0.0004), severe respiratory condition (p=0.003) and diabetes (p=0.02).Conclusions: In this cohort of COPD patients, severe exacerbations for COPD in 2005 were the most prominent risk factor of death between 2006 and 2011. Comorbidities also markedly impacted COPD global mortality.