TY - JOUR T1 - Myositis-associated interstitial pneumonia (MaIP): Autoantibody associations in patients presenting to pulmonologists and rheumatologists JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3809 AU - Sushil Agarwal AU - Emma Helm AU - S.C.H. Smith AU - Shirish Dubey AU - Felix Woodhead Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3809.abstract N2 - IntroductionPolymyositis/Dermatomyositis patients often have interstitial pneumonia (IP). Histology usually shows organising pneumonia (OP) and non-specific interstitial pneumonia (NSIP). They may present either to a pulmonologist (Group A) or a rheumatologist (Group B). Myositis-specific antibodies (MSA) could aid diagnosis in conjugation with clinical phenotype.AimTo compare clinical phenotypes and their MSA associations in patients with HRCT evidence of IP.MethodsClinical presentation and investigation results in each group were reviewed retrospectively.ResultsOf Group A [n=4]; 3/4 (75%) had a respiratory problem and 1/4 (25%) arthralgia as their first symptom. Of group B [n=7]; 4/7 (57%) of whom had myositis, 2/7 (29%) a respiratory problem and 1/7 (14%) arthralgia as their first symptom. MRI of the thighs showed myositis in 6/7 patients in Group B but was only performed in 1/4 patient in Group A and was negative. Anti-Jo1 was the most common antibody in Group B [5/7 (71%) vs 1/4 (25%)]. PL7 and PM-Scl were only seen in Group A.ConclusionMaIP presents with different phenotypes. Myositis is more common in those presenting to rheumatologists. Anti-Jo1 antibodies were most common in patients presenting to rheumatologists whilst PL-7 and PM-Scl were seen in those presenting to pulmonologists. Pulmonologists should be alert to the occurrence of MaIP without frank myositis. ER -