RT Journal Article
SR Electronic
T1 Possible indication for surgical resection of lung cancer associated with combined pulmonary fibrosis and emphysema (CPFE)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2338
VO 42
IS Suppl 57
A1 Yuko Mizokami
A1 Aiko Masunaga
A1 Shinako Yoshitake
A1 Keisuke Kojima
A1 Hiroshi Sakata
A1 Susumu Hirosako
A1 Shinichiro Okamoto
A1 Hidenori Ichiyasu
A1 Kazuhiko Fujii
A1 Naoki Saita
A1 Kentaro Yoshimoto
A1 Takeshi Mori
A1 Makoto Suzuki
A1 Hirotsugu Kohrogi
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2338.abstract
AB Background:The clinical characteristics of CPFE are complicated because impairing %DLco and oxygen desaturation on exertion while %VC and FEV1.0% are almost normally maintained as well as complex lung imaging with fibrosis and emphysema. In addition, CPFE complicates lung cancer at high incidence. However, its indication for surgical resection of the lung cancer and the prognosis after surgery are not assessed. The aim of this study was to clarify the clinical course and prognosis after the surgical resection of lung cancer complicated with CPFE.Methods and Results: We conducted a retrospective study of 28 patients (31 specimens) with surgical resection of lung cancer with CPFE in our hospital from April 2010 to September 2012. The age range was 60-83 years old, and 27 were men, one was woman. In the histological types of 31 specimens, 16 were adenocarcinomata, 11 were squamous cell carcinomata, two were small cell carcinoma, one was adenosquamous carcinoma and one was spindle cell carcinoma. In the preoperative pulmonary function tests, %VC was 99.1 ± 17.9%, FEV1.0% was 71.5 ± 12.4%, %DLco was 73.9 ± 19.9%, A-aDO2 was 19.8 ± 9.9 Torr. The prevalence of acute exacerbation of interstitial pneumonia following operation occurred in two of 28 cases, one case survived and one case died. Two of 27 survived cases required domiciliary oxygen therapy by hypoxemia in one year after surgery. There were no patients died with pulmonary insufficiency by surgery.Conclusion: In the lung cancer patients with CPFE, indication of the surgical resection of lung cancer with CPFE is possible because outcomes of surgery and the prognosis were acceptable.