RT Journal Article
SR Electronic
T1 Chinese herbs in treatment of postinfectious cough: A multi-centre, randomized, double-blind, placebo-controlled trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1595
VO 42
IS Suppl 57
A1 Hongli Jiang
A1 Bing Mao
A1 Ruiming Zhang
A1 Yanling Xu
A1 Jian Ma
A1 Qingping Liu
A1 Faguang Jin
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P1595.abstract
AB Backgroud: Postinfectious cough (PIC) is troublesome when cough persists and adversely affects quality of life (QOL), but there is no reliable and safe medical treatment available.Objectives: T o investigate the efficacy and safety of a Chinese herbal formula Qingfeng Ganke granule (QGG) in treatment of PIC, and to determine whether QGG could improve QOL in patients with PIC.Methods: In a multi-centre, randomized, double-blind, placebo-controlled trial, patients aged 18 to 65 years old were randomly assigned to either group A (6 g of QGG plus 6 g of QGG analogue), group B (12 g of QGG), or group C (12 g of QGG analogue), twice daily for 10 days. All patients finished Cough Quality of Life Questionnaire (CQLQ) at day 1 and day 10. All patients recorded cough frequency and severity on diary card during treatment. The trial was registered with the Chinese Clinical Trial Registry (No.ChiCTR-TRC-12002297).Results: A total of 180 eligible subjects were randomly (1:1:1) assigned to three treatment groups and 12 patients withdrew from the study. QGG significantly improved CQLQ scores compared with placebo (group A: -6.17 [95% CI, -10.4 to -1.88]; P = 0.0258; group B: -9.65 [95% CI, -13.9 to -5.4]; P = 0.0003). There were also significant differences in median duration of cough recovering (> 10 days vs. 8 days vs. >10 days; P < 0.0001) and median duration of cough alleviating (4 days vs. 4 days vs. 6 days; P < 0.0001). Adverse events were reported similarly in three groups (7.02% vs. 7.02% vs. 1.69%; P = 0.3313).Conclusions: QGG improved cough and cough-related quality of life in patients with PIC. QGG can be a clinically valuable intervention in the management of PIC.