PT  - JOURNAL ARTICLE
AU  - Bo Wang
AU  - Haixia Zhou
AU  - Jun Xiao
AU  - Jing Yang
AU  - Chun Wan
AU  - Ting Yang
AU  - Xuemei Ou
AU  - Yulin Feng
TI  - Association of FAM13A polymorphisms with COPD and COPD-related phenotypes in Han Chinese
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - 1522
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/1522.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/1522.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background: Genetic factors are known to contribute to COPD susceptibility and these factors are not fully understood. Genome-wide association studies (GWAS) and integrative genomics approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and FAM13A polymorphisms in non-Asian populations.Objectives: To investigate whether FAM13A polymorphisms would be associated with COPD susceptibility and COPD-related phenotypes in Han Chinese.Methods: Seven single nucleotide polymorphisms (SNPs) in FAM13A gene were genotyped in a case-control study (680 COPD patients and 687 controls).Results: Statistical analysis revealed that SNP rs7671167 was associated with COPD in former smokers with adjusted P-value of 0.026. Five SNPs (rs7671167, rs2869966, rs2869967, rs2045517, and rs6830970) were associated with FEV1/FVC ratio in the entire cohort and rs6830970 was associated with FEV1/FVC ratio in COPD cases (P range 0.003-0.034). Six SNPs (rs7671167, rs2869966, rs2869967, rs2045517, rs1903003, rs6830970) showed strong linkage disequilibrium (r2 ≥ 0.9). Four major haplotypes were observed but showed no significant difference between case and control groups (P = 0.2356, 0.1273, 0.6266 and 0.3006 respectively).Conclusions: The current study suggests that the FAM13A locus might be a contributor to COPD susceptibility in Han Chinese.