RT Journal Article
SR Electronic
T1 Maternal complications and conditions in pregnancy and wheezing in early childhood: A combined analysis of 14 European birth cohorts
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1628
VO 42
IS Suppl 57
A1 Daniela Zugna
A1 Claudia Galassi
A1 Isabelle Annesi-Maesano
A1 Nour Baiz
A1 Henrique Barros
A1 Sofia Correia
A1 Valentina Di Gregori
A1 Liesbeth Duijts
A1 Francesco Forastiere
A1 Mireia Gascon
A1 Hazel Inskip
A1 Vincent W.V. Jaddoe
A1 Maria Pia Fantini
A1 Pernille Stemann Larsen
A1 Anne-Marie Nybo Andersen
A1 John Penders
A1 Maria Skaalum Petersen
A1 Daniela Porta
A1 Ulrike Steuerwald
A1 Jordi Sunyer
A1 Carel Thijs
A1 Martine Vrijheid
A1 Lorenzo Richiardi
A1 Franca Rusconi
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P1628.abstract
AB Aims.We assessed the relationship of maternal complications including hypertensive disorders and diabetes in pregnancy, and pre-pregnancy body mass index (BMI) with wheezing symptoms in infants, combining data from birth cohorts participating in the CHICOS (Developing a Child Cohort Research Strategy for Europe) project.Methods. Eligible cohorts met the following criteria: recruitment from 1990 onwards, maternal complications recorded at any time during pregnancy, and wheezing recorded in the first 12-24 months of life. Associations of maternal complications and ever (≥ one episode), and recurrent (≥4 episodes) wheezing were assessed for each cohort, adjusting for maternal country of birth, education, asthma, smoking in pregnancy, parity, and age. Crude, adjusted and mutually adjusted risks ratios (aRR) were pooled using a random-effects meta-analysis.Results. The analysis included 93245 subjects. Ever wheezing ranged from 20 to 47 %, and recurrent wheezing from 3 to 14%. Pre-eclampsia and obesity (BMI≥ 30; ref: BMI: 18.5-24) were associated with an increased risk of ever wheezing (aRR, 1.09; 95% CI: 1.02, 1.17 and 1.12; 95% CI: 1.07, 1.18, respectively). Both estimates increased slightly for recurrent wheezing. Maternal pre-pregnancy overweight (BMI: 25-29) was associated with an increased risk of wheezing, both ever and recurrent (aRR: 1.09, 95% CI: 1.06, 1.11 and 1.20: 1.13, 1.26, respectively). Neither hypertension nor diabetes were found to be associated with ever or recurrent wheezing.Conclusions. Pre-pregnancy overweight, obesity and pre-eclampsia are associated with a slightly increased risk of wheezing in infants.