RT Journal Article
SR Electronic
T1 CXCR1 is dispensable for allergy-driven airway leukocyte recruitment in vivo
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4740
VO 42
IS Suppl 57
A1 Melanie Carevic
A1 Martina Bakele
A1 Sandra Beer-Hammer
A1 Lauren Mays
A1 Dominik Bloes
A1 Peter Gierschik
A1 Stella Autenrieth
A1 Michael Kormann
A1 Barbara Moepps
A1 Dominik Hartl
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4740.abstract
AB Chemokines recruit inflammatory cells to sites of inflammation. Human CXCL8 (Interleukin 8) represents the prototypical chemokine for neutrophil migration by binding to the G-protein coupled chemokine receptors CXCR1 (IL-8RA, CD181) and CXCR2 (IL-8RB, CD182). While the role of CXCR2 has been investigated in detail by genetic deletion or pharmacologic inhibition, the distinct contribution of CXCR1 remains incompletely understood. The murine homologue of human CXCR1 has recently been identified. Here we studied the role of CXCR1 in leukocyte recruitment by using recently generated CXCR1 knock-out mice and in vivo models of airway inflammation (ovalbumin and house dust mite models of allergic asthma), infection-triggered cell recruitment and chemotaxis. In contrast to human CXCR1, murine CXCR1 was dispensable for the recruitment of neutrophils, monocytes, dendritic cells or T cells in models of allergic or bacterial inflammation. These studies demonstrate that CXCR1 is dispensable for allergy-driven airway leukocyte recruitment and inflammatory cell migration in vivo. The functional role of murine CXCR1 in cell recruitment and pulmonary inflammation remains to be solved in future studies.