RT Journal Article
SR Electronic
T1 Granulocytic myeloid-derived-supressor cells (GrMDSCs) in chronic obstructive pulmonary disease (COPD) patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2156
VO 42
IS Suppl 57
A1 Agata Nowicka
A1 Beata Brajer-Luftmann
A1 Mariusz Kaczmarek
A1 Halina Batura-Gabryel
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2156.abstract
AB COPD increses the risk of developing lung cancer (LC). Development of LC may be connected not only with smoking, but also with genetic predysposition and chronic inflammation. GrMDSCs expand in cancer, inflamation and infection. GrMDSCs activation increses immunosupresive factors expression, that may activate epithelial cells proliferation and support their migration. These processes may lead to neoplasmatic transformation in course of COPD.Aim of the study: assesment of GrMDSCs in COPD patients blood and BAL (bronchoalveolar lavage) and correlation with clinical parameteres. 18 COPD patients were included to cross-sectional study. Immunophenotyping of blood and BAL cells was performed using CD11b, CD33, Lin1, HLA-DR, CD45 (FACSCanto cytometer). PFTs (pulmonary functin tests) and BODE index were performed.Results: We indicated the presence of GrMDSCs in COPD patients blood (Mean 2.75%, SD 1.625, Min. 0.31, Max. 5.23) and BAL (Mean 0.21%, SD 0.459, Min. 0.0, Max. 1.71). We observed correlation between GrMDSCs[%] and age [yr] (rs,0,68, p 0,0099) GOLD stage (rs,0,7, p 0,0080), RV[%] (rs,0,64, p 0,0182), RV/TLC (rs,0,74, p 0,0036) in BAL and between GrMDSCs[%] and age[yr] (rs,-0,63, p 0,0223), paO2[mmHg] (rs,0,57, p 0,0398), FVC[%] (rs,0,66, p 0,0142) in blood. No correlation between GrMDSCs[%] and other PFT parametres (FEV1, TLC, SaO2, paCO2, DLCO), and BODE index was observed.Conclusion: Our findings confirm the presence of GrMDSCs in systemic and local inflammatory process in COPD. Further studies are needed to explain their role in neoplasmatic transformation in course of COPD.