RT Journal Article
SR Electronic
T1 Does non-cystic fibrosis bronchiectasis (nCF-BCt) determine extrapulmonary manifestations?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1355
VO 42
IS Suppl 57
A1 Anderson Alves de Camargo
A1 Tatiane Soares Amaral
A1 Rodrigo Abensur Athanazio
A1 Samia Zahi Rached
A1 Fernanda de Cordoba Lanza
A1 Jenifer dos Santos
A1 Dirceu Costa
A1 Alberto Cukier
A1 Regina Maria Carvalho-Pinto
A1 Celso Ricardo Fernandes Carvalho
A1 Rafael Stelmach
A1 Simone Dal Corso
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P1355.abstract
AB Introduction: Although nCF-BCt is a chronic and debilitating disease, its extrapulmonary effects have been poorly described in the literature. Objective: To evaluate the effects of nCF-BCt on exercise capacity, peripheral muscle strength, physical activity in daily life (PADL), and health-related quality of life (HRQoL) in adult subjects. Methods: Eighty subjects (50 women; 44 ± 14 yrs; fat-free mass index: 17 ± 2 kg/m²) with nCF-BCt and 30 healthy subjects (18 women; 44 ± 15 yrs; fat-free mass index: 17 ± 2 kg/m²) were evaluated. The subjects performed maximum voluntary isometric contraction of the quadriceps femoris (MVIC-QF), the incremental shuttle walking test (ISWT), and a maximum cardiopulmonary exercise test. PADL was assessed by the number of steps taken, calculated over three consecutive days (Yamax, PW-610 model, Tokyo, Japan). Dyspnea was rated according to the Medical Research Council (MRC) scale, and HRQoL was assessed using the SF-36 Health Survey Questionnaire. Results: Compared with the controls, the subjects with nCF-BCt presented with reduced aerobic capacity (VO2: 81 ± 15 vs 63 ± 13% pred; p < 0.001), functional capacity (ISWT distance: 73 ± 15 vs 52 ± 13% pred; p < 0.001), and MVIC-QF (26 ± 11 Kg vs 22 ± 10 Kg; p= 0.046). Lower PADL was also observed in the nCF-BCt patients (9526 ± 5843 vs 12009 ± 6031; p = 0.052), as well as poor HRQoL in most domains (statistically significant), except for pain and mental health. Conclusion: nCF-BCt is associated with extrapulmonary manifestations characterized by reduced exercise capacity, muscle strength, and PADL beyond impairment of HRQoL.