RT Journal Article
SR Electronic
T1 ERICA (<span class="underline">e</span>valuating the <span class="underline">r</span>ole of <span class="underline">i</span>nflammation in <span class="underline">c</span>hronic <span class="underline">a</span>irways disease): Extrapulmonary manifestations of COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4848
VO 42
IS Suppl 57
A1 Divya Mohan
A1 Carmel McEniery
A1 Nicola Gale
A1 Jonathan Fuld
A1 Charlotte Bolton
A1 William MacNee
A1 Peter Calverley
A1 Ruth Tal-Singer
A1 Ian Wilkinson
A1 Michael Polkey
A1 John Cockcroft
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/4848.abstract
AB IntroductionERICA is a longitudinal study investigating the significance of cardiovascular (CV) and skeletal muscle (SM) manifestations of COPD and fibrinogen in relation to death/admission. This midpoint analysis asks whether the CV &amp; SM manifestations represent the same patient subsets.MethodWe measured blood pressure (BP), spirometry, fibrinogen, 6 min walk distance (6MW), quadriceps maximal voluntary contraction force (MVC), and aortic pulse wave velocity (PWV). We defined CV manifestation as PWV&gt;10m/s (EHJ 2010;31: 2338) and SM weakness as MVC/BMI ratio&lt;1.2 (Thorax 2007 62:115).ResultsTable 1 presents data from the first 318 of a planned 800 patients, grouped according to presence of CV and/or SM manifestations, with Group 1 (SM) N=95, Group 2 (CV &amp; SM) N=80, Group 3 (neither CV/SM) N=78 and Group 4 (CV) N=65 (Fig 1).View this table:Table 1ConclusionAnalysis of data from COPD patients enrolled in ERICA thus far suggests that there are distinct CV and SM subsets.