RT Journal Article SR Electronic T1 Effects of caregiver depression on child depression and asthma: Mediation by inter-parent conflict and negative parenting JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4308 VO 42 IS Suppl 57 A1 Wood, Beatrice A1 Lim, JungHa A1 Miller, Bruce YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P4308.abstract AB Caregiver and child chronic stress and depression are linked with poor outcomes in child asthma, mediated by poor disease management and/or by psychobiologic stress mechanisms. Pathways of effect are unknown. Purpose: Our goal is to elucidate pathways. We hypothesize that parent depression contributes to inter-parent conflict and negative parenting which contribute to child depression (CD), which in turn predicts asthma disease activity (ADA). Methods: Asthmatic children (N=106,age 7-17), fathers and mothers were studied. Parent depression was indexed by self-report BDI. Inter-parent and parenting behavior was observed and rated during stressful family interaction tasks. The Iowa Family Rating Scale was used, intra-class correlations:79-.83. The CDI and Clinician Ratings indexed CD. NHLBI criteria indexed (ADA).Results: Structural equation modeling showed a pathway from mother depression (MD) to child depression (CD) mediated by negative parenting. X2 (32,N=106) =57.50,p=.004, IFI=.89, CFI=.87, RMSEA=.09. CD predicted ADA (B=.28,p=.05). Father depression (FD) was linked to negative parenting (B=.29,p=.001) and to inter-parent conflict (B=.32,p=.01) but father negative parenting was not linked to CD. However, FD contributed to inter-parent conflict which contributed to negative MATERNAL parenting which was linked with CD and ADA. Conclusions: MD predicted CD and ADA, mediated by negative parenting, whereas FD predicted inter-parent conflict, which predicted CD and ADA mediated by maternal negative parenting. These findings suggest that father and mother depression both play a role in child depression and asthma disease activity, but through different pathways.