TY - JOUR T1 - Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension and their relationship with right ventricular structure and function JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4088 AU - Anna Agnese Stanziola AU - Guido Carlomagno AU - Carolina Vitale AU - Maurizia Lanza AU - Valentina Mercurio AU - Serafino Fazio AU - Matteo Sofia Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4088.abstract N2 - Prognostic stratification in pulmonary arterial hypertension (PAH) relies on clinical assessment and invasive hemodynamic measurements. However, right ventricular (RV) dilatation and function, assessed by cardiac magnetic resonance (CMR), have been demonstrated to predict survival independent of invasive indices. Soluble ST2 (sST2),a marker of cardiomyocyte stress related to the IL33/IL1-receptor system, increases in heart failure, especially when RV overload is present. Aim of this study was to explore sST2 and IL-33 levels in PAH, and to evaluate their possible correlation with cardiac remodeling as assessed by CMR25 patients with PAH underwent contrast-enhanced CMR and measurement of serum sST2, IL-33 and NT-proBNP levels.10 age-matched healthy individuals with a negative echocardiogram served as controls.PAH patients showed increased sST2 levels compared with controls. Patients with sST2 levels above and below the median differed significantly in terms of WHO class, walking distance, RV diastolic and systolic volume indices, and ejection fraction. Analysis of CMR data showed strong correlation of sST2 levels with right ventricular end-systolic volume and NT-proBNP, as well as a significant negative correlation with RV ejection fraction. Regression analysis suggested independent predictive value of the two biomarkers with respect to RV function.Serum sST2 levels are elevated in patients with PAH, and they are strictly correlated with the severity of right heart remodeling and dysfunction. sST2 appears as a promising novel biomarker and a potentially useful tool for the non- invasive assessment of RV dysfunction. ER -