RT Journal Article SR Electronic T1 Neurocognitive impairment in children with obesity and sleep disordered breathing JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4669 VO 42 IS Suppl 57 A1 Alessandra Tabarrini A1 Silvia Miano A1 Anna Rita Mazzotta A1 Simona Bianchi A1 Alessandro Ferretti A1 Luca Brasili A1 Manuela Cecili A1 Maria Pia Villa YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P4669.abstract AB Aims:To compare neurobehavioral disorders in children with Sleep-Disordered Breathing (SDB), with SDB and obesity and in normal controls.Methods: We studied 36 children with SDB (Group 1: M/F 21/15; mean age 8.29±2.04 years, body mass index, BMI, percentile 62,61±29,65), 38 children with SDB and obesity (Group 2: M/F 27/11; mean age 8.73±1.69 years, BMI percentile 116,52±15,95) and 58 non obese control (Group 3: M/F 29/29; mean age 8.89±1.62 years).Groups 1 and 2 underwent clinical evaluation, overnight polysomnography, Attention Deficit/Hyperactivity (ADHD) rating scale and neurocognitive assessment based on Wechsler Intelligence Scale for Children (WISC-R). Group 3 underwent clinical interview and neurocognitive assessment.Results. Verbal Intelligence Quotient (VIQ), Performance Intelligence Quotient (PIQ) and Full-Scale Intelligence Quotient (FSIQ) were lower in groups 1 e 2 than in controls (VIQ 98,11 ± 12,68 vs 91,78±16,11 vs 109,63±12,04; PIQ: 100.63±14.98 vs 93.92±14.89 vs 117.27±11.96; FSIQ: 96.75±13.51 vs 91.81±13.97 vs 114.93±11.05, respectively) (p<0.05).A positive correlation between PIQ and age of onset of SDB (r= 0,335, p=0,04) was found in group 1. A positive correlation between VIQ and age of onset of SDB (r=0,335, p=0,05) and a negative correlation between VIQ and duration of SDB (r=-0,362, p=0,02) PIQ and BMI percentile (r=-0,341, p=0,03), FSIQ and Apnea/Hypopnea index (r=-0,321, p=0,05) were found in group 2.ADHD scores correlated negatively with IQ scores in all subjects. Group 1 had the highest hyperactivity score.Conclusions. Children with obesity and SDB showed the highest cognitive impairment while children with only SDB the highest hyperactivity score.