RT Journal Article
SR Electronic
T1 Patient education via tablet-pc vs. conventional to improve compliance with immunosuppressive drug regimen after lung transplantation - a randomized controlled trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2685
VO 42
IS Suppl 57
A1 Hendrik Suhling
A1 Jessica Rademacher
A1 Imke Zinowsky
A1 Jan Fuge
A1 Mark Greer
A1 Gregor Warnecke
A1 Tobias Welte
A1 Jacqueline Smits
A1 Jens Gottlieb
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2685.abstract
AB Non-compliance of immunosuppression after lung-transplantation provokes rejection, infection and renal insufficiency. This study was carried out to determine whether tablet-pc education is non-inferior to conventional, face-to-face, education by a specialist for improvement of immunosuppression levels after lung-transplantation.A single-centre (Medical School of Hannover), randomised controlled trial with 6 months follow-up, including patients with less than 50% of calcineurin inhibitor trough levels in target range in last 6 months was initiated.64 patients were randomised, stratified only by underlying disease of cystic fibrosis. 6 months after inclsuion, mean improvement of a single education was 26% of calcineurin inhibitor trough levels in target range. Primary end-point of non-inferiority was reached, a two-sided t-test revealed no difference between types of education (p = 0.17, see figure 1). Trough level variability decreased (tablet-pc: 22.9% and 17.9% conservative, p = 0.13), interval adherence remained unchanged. Knowledge about immunosuppression improved after 6 months by 44%. Instruments to measure compliance (ITBS, Morisky, ECS) demonstrated good compliance without showing differences between the groups.Conclusion: Tablet-pc education was non-inferior to conventional education with impressive improvement after one education.