TY - JOUR T1 - An increased respiratory drive accounts for the severity of dyspnea in systemic sclerosis JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P1926 AU - Maarten Ninaber AU - Willem Hamersma AU - Anne Schouffoer AU - Annemie Schuerwegh AU - Jan Stolk Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P1926.abstract N2 - IntroductionDyspnea in progressive systemic sclerosis (SSc) may originate from pulmonary hypertension or interstitial lung disease. Respiratory drive is a major determinant of dyspnea. Evaluation of the respiratory drive measured by mouth occlusion pressures and CO2 rebreathing may better relate to the magnitude of dyspnea than the severity of gas transfer or lung volume impairment.MethodsIn 73 SSc patients referred to a targeted outpatient health care program PFT as well as mouth occlusion pressures after 0.1 sec (P0.1) were measured while breathing room air at resting ventilation and during rebreathing of a gas mixture containing 7% CO2 and 93% O2. An abnormal V’E/P0.1 is defined as < 8 L/min/cmH2O (Scott GC, Burki NK. Chest 1990;98:900-06). Dyspnoea scores were assessed by the USCD dyspnoea scale (Eakin EG et al. Chest 1998;113:619-24).ResultsMean P0.1 in patients with normal normal V’E/P0.1 (n=45) was 1.1 ± 0.04 and in patients with abnormal V’E/P0.1 (n=28) 1.6 ± 0.08 cmH20, p <0.001. ΔP0.1/Δ PetCO2 differed significantly between these groups (0.75 versus 0.45 cmH20/mmHg, P<0.001), as well as FEV1, FVC and DLCO. No significant difference was present in ΔV’E/Δ PetCO2. V’E/P0.1 showed the highest significant correlation with the USCD dyspnoea scale (r= -0.76, p <0.001). In a binary logistic regression model the USCD dyspnea scale was the only predictor for an abnormal V’E/P0.1 (OR 4.68, CI: 3.17-6.91).ConclusionIn SSc with an abnormal V’E/P0.1, an increased respiratory drive to CO2 is present and accounts for the severity of dyspnea. ER -