RT Journal Article SR Electronic T1 Prognosis of pneumocystis jirovecii pneumonia in non-HIV patients JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2759 VO 42 IS Suppl 57 A1 Zehra Nur Töreyin A1 Pervin Ekren A1 Ayse Caner A1 Seray Töz A1 Alev Gürgün A1 Hatice Uluer A1 Feza Bacakoglu YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2759.abstract AB Pneumocystis jirovecii pneumonia (PcP) is an opportunistic infection which can have different prognosis and progression among patients with HIV and non-HIV. It is still controversial whether Cytomegalovirus (CMV) co-infection worsens the prognosis or not. In this retrospective study, we aimed to investigate the effect of CMV co-infection in the prognosis of patients with PcP.In the study 20 immunocompromised non-HIV PcP (median age 54.3±15.3 yrs, 13 males) patients who were admitted to our clinic from January 2009 to December 2012 were included. Demographic characteristics of the patients, immunosupressive therapy, anti-microbial prophylaxis, clinical, laboratory, radiological findings, the diagnostic method, the data for the presence and treatment of co-infection and respiratory failure were recorded.On admission, 16 (80%) of the patients were on corticosteroid treatment. The median APACHE II Score was 19.0 (9-40), PaO2/FiO2 ratio was 147.5 (78-471). PcP diagnosis was made by microscopic examination in 2 cases and by PCR in 14 cases while in 4 cases both method was used. During follow-up, co-infection occured in 17 (85%) of the patients. 16 (80%) of them developed ARDS, 17 (85%) of the patients required invasive mechanical ventilation and 14 (70%) of them died. Mortality rates were higher in patients who developed ARDS, were intubated and co-infected (p=0.01, p=0.018, p=0.018, respectively). Twelwe (70.8%) of the patients had CMV co-infection. Progression to ARDS and intubation rates were higher (p=0.036 and p=0.049, respectively) in these patients.In conclusion; among the non-HIV patients with PcP, progression to ARDS and mortality rates are higher in the presence of co-infection especially with CMV.