@article {Campos-Rodriguez3045, author = {Francisco Campos-Rodriguez and Miguel A. Martinez-Garcia and Antonio Martorell-Calatayud and Amalia Perez-Gil and Eduardo Nagore and Irene Valero-Sanchez and Maria J. Selma-Ferrer and Eusebi Chiner-Vives and Pedro Landete and Josep M. Montserrat and Cristina Carreras and Ramon Farre}, title = {Association between markers of aggressiveness of malignant cutaneous melanoma and sleep disordered-breathing}, volume = {42}, number = {Suppl 57}, elocation-id = {3045}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Background. Recent studies in humans have shown an association between sleep-disordered breathing (SDB), including overnight hypoxia, and the incidence and mortality of cancer, but no study has focused on a specific type of cancer. The objective of this study was to analyze the relationship between some markers of cutaneous malignant melanoma (CMM) aggressiveness and the severity of SDB.Methods. We performed a prospective, multicenter observational study in 56 consecutive patients diagnosed with CMM. Measurements of CMM aggressiveness included: number of mitosis/mm2, Breslow Index, presence of ulceration and growth rate of melanoma (GRM). Every participant underwent a diagnostic respiratory polygraphy. Multivariate analyses were used to investigate the independent relationship between SDB severity measured by the apnoea-hypopnoea index (AHI) and oxygen desaturation indexes (ODI3\% and ODI4\%) and markers of CMM aggressiveness.Results. The prevalence of SDB (AHI>=5) in the cohort was 60.7\% and severe SDB (AHI>=30) was present in 14.3\% of the patients. In fully adjusted multivariate analyses, AHI (OR 1.17; 95\%CI 1.03-1.34), ODI3\% (OR 1.14; 95\%CI 1.03-1.26) and ODI4\% (OR 1.3; 95\%CI 1.04-1.45) were independently associated with an increased GRM. Furthermore, AHI, ODI4\% and ODI3\% correlated with other aggressiveness factors of CMM, such as the Breslow Index, presence of ulceration and mitotic index.Conclusion. SDB severity independently predicts aggressiveness of cutaneous malignant melanoma.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/3045}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/3045.full.pdf}, journal = {European Respiratory Journal} }