RT Journal Article
SR Electronic
T1 Clinical features and CT findings of anti-Jo-1 antibody positive interstitial lung disease with or without polymyositis and dermatomyositis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3810
VO 42
IS Suppl 57
A1 Tanaka, Maki
A1 Arita, Machiko
A1 Tachibana, Hiromasa
A1 Ishida, Tadashi
A1 Nakazawa, Takashi
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P3810.abstract
AB Background: Anti-Jo-1 antibodies are specific for polymyositis and dermatomyositis (PM/DM). The correlation between the presence of the anti-Jo-1 antibodies and interstitial lung disease (ILD) is very high. Clinical differences for patients with anti-Jo-1 antibody positive ILD without a PM/DM diagnosis are yet to be established.Aim: To clarify the differences in clinical characteristics, the clinical course, and radiological findings between anti-Jo-1 antibody positive ILD patients with and without a PM/DM diagnosis.Methods: Twenty-three patients were diagnosed with anti-Jo-1 antibody positive ILD at our hospital between May 1995 and March 2012, inclusive. We evaluated the symptoms, clinical presentation (acute or gradual onset) and dominant chest computed tomography (CT) findings.Results: Eleven patients were diagnosed with PM/DM. Eight patients (72%) from the PM/DM group and four patients (33%) from the non-PM/DM group presented with ILD of acute or sub-acute onset (p=0.099). Predominant high-resolution CT scan patterns were diffuse ground-glass opacity, reticular shadow, and consolidation with traction bronchiectasis. Distribution was basal-predominant peripheral and along the bronchovascular bundle.Conclusion: Although there were more patients in the PM/DM group with an acute and sub-acute clinical course, there was no significant difference between the PM/DM and non-PM/DM groups for clinical characteristics, CT findings and prognosis, respectively. Our study suggests that anti-Jo-1 positive ILD patients without PM/DM groups can be treated based on the clinical course of anti-Jo-1 positive ILD with PM/DM.