TY - JOUR T1 - Parent-reported recurrent wheeze after RSV lower respiratory tract infection versus non-RSV lower respiratory tract infection JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4321 AU - Saskia Tamminga AU - Loes Nibbelke AU - Maarten Blanken AU - Louis Bont Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4321.abstract N2 - BACKGROUND Respiratory syncytial virus accounts for fifty to eighty percent of the hospitalizations for lower respiratory tract infection (LRTI) hospitalizations. In term infants, RSV LRTI has a more severe course than non-RSV LRTI, while both types are associated with recurrent wheeze. Differences in recurrent wheeze after RSV LRTI versus non-RSV LRTI are not known in otherwise healthy late preterm infants.OBJECTIVES The aim of this study was to compare the incidence of parent reported recurrent wheezing in the first year of life in late preterms after hospitalization for RSV LRTI versus non-RSV LRTI.METHODS This prospective study included 3104 infants born between 33-35 weeks of gestation at 41 participating hospitals across the Netherlands. A parental questionnaire about clinical and demographic characteristics of the infant was completed at birth and at the age of one year. In case of admission for LRTI, clinical details were obtained.RESULTS We found that 196 infants were hospitalized for LRTI (RSV, n=138; non-RSV, n=44, unknown, n=14). RSV LRTI was associated with longer duration of hospitalization (5 versus 3 days, p<0.05), more frequent oxygen requirement (60% versus 27%, p<0.001). Similar proportion of recurrent wheeze occurred after hospitalizations for RSV LRTI (n=64, 48%) versus non-RSV LRTI (n=23, 54%).CONCLUSION Although RSV LRTI has a more severe course than non-RSV LRTI in late preterms, the incidence of subsequent recurrent wheezing during the first year of life is similar in both types. This suggests distinct mechanisms of disease severity and reactive airway disease following viral LRTI during the first year of life in late preterms. ER -