RT Journal Article
SR Electronic
T1 A retrospective analysis of quinolone prescriptions for tuberculosis in two North Birmingham hospitals
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2817
VO 42
IS Suppl 57
A1 Guy Hagan
A1 Dwight McLeod
A1 Nazim Nathani
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2817.abstract
AB IntroductionFew guidelines exist on appropriate use of quinolones in TB management; American and British guidelines suggest a role in liver and renal disease. Ongoing phase III trials may further define their role. Advantages include once daily dosing and no cross-resistance, however inappropriate quinolone use may compromise MDRTB treatment.Aims and objectivesWe sought to analyse the reasons and duration of quinolone prescription for TB in our two hospitals.MethodsPharmacy prescriptions from 1st Nov 2010 to 1st Nov 2012 for quinolones were analysed and TB patients identified. Information was obtained from case note review. Follow up was until 1st Dec 2012.Results33 patients were identified. Mean age was 46.9(+/- 16.4) years. 23 were male, 2 patients HIV+ve. 31/33 TB cases were confirmed on culture; 4 had mono-resistance, and 5 were MDRTB. Sites were pulmonary(13), miliary(8), lymph node(5), meningitis(2), peritoneal(2), spinal(2) and a cold abscess(1). Reasons for quinolone prescription are below:View this table:Quinolones were well tolerated and no patients suffered adverse effects. 30 patients were prescribed moxifloxacin and 3 levofloxacin. 4 patients died during the follow up period, 2 from TB and 2 from malignancy.ConclusionsQuinolone use for TB in our hospitals is appropriate; duration of quinolone prescription could be reduced to preserve the efficacy of this important drug class.