PT - JOURNAL ARTICLE AU - Joan Soriano AU - Nicolas Roche AU - John Cockcroft AU - Klaus Rabe AU - Mark Kearney AU - Guy Brusselle AU - Frits Franssen AU - Francisco Garcia Rio AU - Bo Lundbäck AU - Helen Marsden AU - Hana Muellerova AU - Paul Bloomfield AU - Gilbert Nadeau AU - Mathieu Vasselle AU - Zoe Adams AU - Angus Henderson AU - Leo Fabbri TI - Prevalence and under-diagnosis of airflow limitation and other lung function abnormalities in patients with ischaemic heart disease: an interim analysis of the ALICE study DP - 2012 Sep 01 TA - European Respiratory Journal PG - P450 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P450.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P450.full SO - Eur Respir J2012 Sep 01; 40 AB - Background: Although ischaemic heart disease (IHD) and chronic pulmonary diseases, eg COPD, share similar risk factors, the prevalence and rate of diagnosis of airflow limitation (AL) compatible with COPD, and other lung function abnormalities, in patients with IHD are largely unknown.Methods: In a cross-sectional study conducted in 15 sites across nine European countries (Belgium, France, Germany, Greece, Ireland, Italy, the Netherlands, Spain, and Sweden), we investigated the prevalence of airflow limitation compatible with COPD (defined as post-bronchodilator (BD) FEV1/FVC <0.70) and other lung function abnormalities in outpatients with documented IHD who were ≥40 years, and current or former smokers. Each participant completed a core questionnaire and performed full pre- and post-BD spirometry. Quality control of spirometry readings was performed by a centralized system.Results: Up to April 2012, we studied 1803 evaluable IHD patients, 86.0% male, mean±SD age of 65.0±9.8 years. The prevalence of AL was 30.6% (95% C.I. 28.5%-32.8%, n=552) and, from 547 with available data, only 29.4% (n=161) of these had a prior diagnosis of COPD. In addition, we found a restrictive lung disease prevalence of 11.0% (defined as pre BD FVC<80% predicted and post BD FEV1/FVC≥70% predicted) in a subset of 1685 patients with available data.Conclusions: Airflow limitation, compatible with COPD, and spirometry results suggestive of restrictive lung disease are frequent in individuals with IHD and are largely under-diagnosed, which has implications for the treatment and prognosis of both respiratory and cardiovascular diseases.